Smartox Biotechnology
离子通道研究用多肽**的专业化生产商
Smartox Biotechnology是全球唯壹一家专门生产动物毒液多肽**，用于细胞离子通道功能研究的生物医药米乐。多肽**在生物制药领域具有重要的使用价值。
Smartox Biotechnology于2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)的Michel de waard博士创立,Smartox Biotechnology专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为**）。De Waard博士研究离子通道与**多肽的关系，尤其是鉴定、开发**多肽作为**性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年，Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO奖(OSEO prize for emerging businesses)”。
总之，Smartox Biotechnology提供一系列高质量、具开创价值的多肽**。这些化合物在离子通道 研究中具有高的亲和性和选择性，是相应领域科学研究理想的生物**提供商和贴心的合作伙伴。
Smartox Biotechnology的**产品包括：
钠离子通道(Sodium channel)
Toxin name
Catalog #
Target
Phrixotoxin-3
13PHX003
Selective blocker of Nav1.2
µ-conotoxin GIIIB
CON020
Selective blocker of Nav1.4
µ-conotoxin CnIIIC
CON021
μ-conotoxin PIIIA
08CON006
Jingzhaotoxin-III
12JZH003
Selective blocker of Nav1.5
ProTx-II
07PTX002
Selective blocker of Nav1.7
ProTx-II Biotin
12PTB002
ProTx-I
12PTX001
Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7
Huwentoxin-I
07HWT001
Blocker of TTX-S
Huwentoxin-IV
08HWT002
Hainantoxin-III
13HTX003
Hainantoxin-IV
12HTX001
GsAF-I
12GSF001
GsAF-II
12GSF002
钾离子通道(Potassium channel)
KCa channels
Description
Apamin
08APA001
SK1, SK2, SK3
Charybdotoxin
11CHA001
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
Iberiotoxin
12IBX001
KCa1.1
Leiurotoxin 1 (Scyllatoxin)
10LEI001
Tamapin
10TAM001
Kaliotoxin-1
08KTX002
BK, Kv1.1, Kv1.2, Kv1.3
Kv channels
ShK
08SHK001
Kv1.3, Kv1.1, Kv1.4, Kv1.6
TMR-ShK
SAT001
Kv1.3, Kv1.1
Margatoxin
08MAG001
Kv1.3
(Dap22)-ShK
13SHD001
ADWX-1
13ADW001
HsTx1
08NEU001
Kv1.3, Kv1.2
Agitoxin-2
13AGI002
Maurotoxin
08MAR001
Kv1.2, KCa3.1
Guangxitoxin 1E
11GUA002
Kv2.1, Kv2.2
Stromatoxin 1 NEW
SCT01
Phrixotoxin-2
PHX002
Kv4.2, Kv4.3
AmmTx3 NEW
AMX001
A-type potassium channels
Inwardly rectifying potassium channels
TertiapinQ
08TER001
Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1
hERG/Kv11.1
BeKm-1
13BEK001
ERG1
钙离子通道(Calcium channel)
High voltage-gated Ca2+ channels
Catalog#
ω-agatoxin IVA
11AGA001
P/Qtype
ω-Conotoxin MVIIC
08CON002
P/Qtype, N-type
ω-Conotoxin MVIIA
08CON001
N-type
ω-Conotoxin GVIA
08CON003
ω-Conotoxin SO3
08CON013
Huwentoxin I
T-type, L-type
Intermediate voltage-gated Ca2+ channels
SNX482
08SNX002
R-type
Low voltage-gated Ca2+ channels
T-type
Ryanodine receptors
Maurocalcine
07PAU001
Ryr1
氯离子通道(Chloride channel)
Chlorotoxin
08CHL001
Blocker of small conductance Cl- channels
GaTx1
13GTX001
Selective blocker of CFTR channel
GaTx2
10GTX002
Selective blocker of ClC-2 channel
乙酰胆碱受体(Acetylcholine receptor)
α-conotoxin PeIA
13CON017
α9α10, α3β2 subunits
αC-Conotoxin PrXA
13CON016
α1/β1/ε/δ, α1/β1/γ/δ subunits
Waglerin-1
12WAG001
MusclenAChR
α-conotoxin MI
08CON012
α1/δsubunits
α-conotoxin GI
08CON005
α/δsite
α-conotoxin IMI
08CON011
α7 homomeric nAChR
α-conotoxin GID
CON019
Blocker of α3β2, α7 and α4β2 nAChRs
含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G选择性、特异性抑制含NR2B的NMDAR。Conantokin-G能剂量依赖性抑制Ca2+内流，抑制NMDA诱导的兴奋性中毒效应。研究表明，在小鼠皮层神经元，Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM。
酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)
APETx2
07APE002
Selective blocker of ASIC3
Psalmotoxin1/PcTx1
13PCT001
Selective blocker of ASIC1a
Ugr9-1
13UGR001
Blocker of ASIC3
瞬时受体电位(TRP channel, transient receptor potential)
GsMTx4
08GSM001
TRPC, TRPA
Vanillotoxin3
10VAN003
Activator of TRPV1
Antagonist of TRPA1
嘌呤能通道(Purinergic channel)
Purotoxin-1
选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道，在大鼠DRG神经元上，使用膜片钳实验表明：PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP和100 µM α,β Methylene-ATP浓度下Purotoxin-1对P2X3受体有选择性作用，在该ATP浓度下Purotoxin-1对P2X2和杂化二聚体P2X2/3并无激动作用。
Purotoxin-1对疼痛的潜在**作用。
其它膜受体通道(Others)
Smartox Biotechnology还提供其他类型的膜受体抑制剂：
Morphiceptin
011CAS001
Agonist of µ-opoid receptors
Lys-conopressin G
11CON14
Vasopressin-like peptide
Mechano sensitive ion channels
Obtustatin
10OBT001
Blocks the binding of α1β1 integrin to collagen IV
Rho-Conotoxin TIA
CON022
Blocks α1-adrenergic receptor
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